Differin Gel must be used with utmost care. First, gently cleanse the skin and dry it before touching the product/gel. Also, cover the entire troubled area with a thin layer. For instance, if any individual have an acne on their face, apply the product all over the face.
However, do not use it more than once a day. Applying more than approved will not give better or faster results, but the Differin Gel may make skin irritation worse and therefore children under twelve years should not prefer the usage.
In animal studies of the Differin Gel, adapalene was well undergone when applied dermally for up to six months in rabbits and also up to two years in mice. The main indication of oral toxicity noted in all the animal species was associated with hypervitaminosis A syndrome and involved bone dissolution, developed alkaline phosphatase, and mild anemia.
High oral portions of adapalene have not allowed adverse neurological, cardiovascular, or respiratory effects in the animals. Studies with adapalene were presented in mice at cutaneous doses of 0.6.2 and 6 mg / kg / day and in rats at oral dosages of 0.15, 0.5 and 1.5 mg / kg / day.
The only notable result was a statistically meaningful increase in the benign adrenal phyllo-astrocytomas in male rats given adapalene 1.5 mg/kg/day. These differences are unlikely to be relevant to the cutaneous use of adapalene and it causes oral teratogenic effects in rats and rabbits.
At dermal doses up to 200 times the therapeutic dose and building circulating plasma levels of adapalene that are at least 35 to 120 times greater than the plasma levels displayed in therapeutic use, adapalene developed the incidence of extra ribs in the case of rats and rabbits, without raising the incidence and greater deformations.
- Store the gel at room temperature between 68 ° C and 77 ° F.
- Protect from adhesive freezing.
- Propylene Glycol, Purified Water, and also Sodium Hydroxide.
- May include hydrochloric acid to adjust pH.